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Second, we will introduce several representative computational methods that utilize data from various omic dimensions, including genomics, epigenomics, and transcriptomics from section “Single-omics” to section “Integration of Multi-omics Data”, discuss strategies for enhancing the performance of drug synergy prediction models through the integration of multi-omics data in section “Integration of Drug Structure Information or Systems Pharmacology with Multi-omics Data”, and summarize a timeline of the models mentioned in this review (Fig

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Additionally, we noted a decline in metabolites involved in cell structural synthesis, such as UDP-N-acetylmuramate, a vital component of the cell wall, UDP-N-acetyl-D-mannosamine, integral to the cell membrane, and fuculose 1-phosphate