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Pregnant and breast feeding women who are low in B12 should only receive smaller doses.

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Importantly, peptide analogs with stapling moieties present at the hydrophobic interface (1914, 1919, 1921, 2015, 2017) had limited improvement or even loss of activity compared to LD2, suggesting that substitution of these interfacial residues disrupted key hydrophobic interactions (Table 1)