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The net proliferative effects of glutamine in these cell types are likely to result from the role of glutamine as a major fuel source, in purine and pyrimidine synthesis, and in stimulation of cell signaling pathways involved in cell proliferation and inhibition of apoptosis (1, 21, 40, 41)

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Glucose toxicity in beta-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection