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Given that adrenoceptors, as the predominant targets of the catecholamines, orchestrate a complex network of signal transduction pathways and cellular responses, polymorphic variation at these receptors will undoubtedly result in substantial interindividual differences in human physiology and disease

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They found that OCCC cells were more resistant to carboplatin than OSC cells, and that the inhibition of GSH production by BSO sensitized these cells to carboplatin, both in vitro and in vivo [57]