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Role of Protein Kinase C in Phosphorylation and Desensitization There has been considerable interest in the role of PKC phosphorylation in the regulation of MOR by morphine (Kelly et al., 2007) since the demonstration that morphine-induced MOR desensitization but not DAMGO-induced desensitization is reduced by PKC inhibition in HEK293 cells (Johnson et al., 2006) and that activation of PKC enhances the rapid desensitization induced by morphine and ME (but not DAMGO) in native locus coeruleus neurons (Bailey et al., 2004, 2009a)

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(2015) Clinical experience in decreasing mercury load