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There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49

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Get started In clinical trials of the oral Wegovy® (semaglutide) pill, participants taking the medication with diet and exercise achieved average weight loss of about 14%–17% over ~64 weeks compared with ~2% with placebo