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While it is beyond the scope of this paper, a number of options are available to address parts of this proposed cycle of gut dysfunction and endogenous toxicity (Table 5)

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Second, BPC-157 is often presented as if its animal healing data directly translates to human recovery timelines, which ignores that rodent models have notoriously poor translational validity for musculoskeletal compounds (Leung et al., 2022, Frontiers in Pharmacology, noted this explicitly in peptide review contexts)