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Why some studies show no effect: Participants with adequate baseline carnitine concentrations Study durations under 8 weeks Doses below 1,500 mg/day Lack of a calorie deficit or exercise component L-carnitine supplementation can lead to a modest reduction in body weight and fat mass, but l carnitine works best when combined with exercise and a proper diet

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Further investigation is warranted to determine whether targeting local iron export mechanisms could alleviate ferroptosis-related cartilage degeneration