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As an effector molecule, NO participates in antimicrobial responses and cooperates with oxidative stress processes to amplify inflammatory signaling, thereby being associated with an M1-like pro-inflammatory program (45)

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Mechanotransduction of Circumferential Stretch Elevated venous pressure in the lower extremity veins during prolonged standing generates circumferential stretch of the vein wall and imposes mechanical stimulation on both ECs and SMCs