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Skin and connective tissue: Estrogen binds to receptors on cells that produce collagen, so collagen production declines as estrogen levels fall

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Smac-mimetics are synthetic, cell membrane permeable peptides consisting of the 4 N-terminal amino acids of Smac, a protein naturally found in mitochondria that antagonizes cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein 2 cIAP2, which is related to downstream effects of mTOR-activated overproliferation [114]

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