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doi:10.1089/ars.2017.7136

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Further, we showed that GH stimulates association of the guanine nucleotide exchange factor SOS with Shc, and the activation of Ras, Raf, MEK and Erks 1 and 2 with a time course consistent with Erks 1 and 2 being activated via a Shc-grb2-SOS-Ras-Raf-MEK-Erk1/2 pathway