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Exposure to 17β-estradiol upregulates the anti-apoptotic protein Bcl-2 while downregulating Bcl-XL, highlighting hormone-mediated modulation of apoptosis ( Figure 3 ) ( Figure 3 Human epidermal growth factor receptor 2/neuroglialoblastoma-derived oncogene (HER/2neu), a proto-oncogene located on chromosome 17q11.2-q12, is a well-recognised tumour-associated marker