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The 2016 approval for the treatment of ROS1 -positive metastatic NSCLC was based on a multicenter, prospective, single-arm trial enrolling 50 patients whose tumors were determined to be ROS1 -positive by fluorescence in situ hybridization (FISH) (96%) or reverse transcription polymerase chain reaction (RT-PCR) (4%) assays

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Simultaneously, the hepatoprotective effect is doubly relevant: it addresses hyperthyroidism-induced hepatic dysfunction and also protects against drug-induced or metabolic-associated liver injury in diabetic patients