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Excessive inflammatory cytokines can exacerbate damage to the heart and surrounding tissues, prolong recovery time, and even increase the risk of adverse events during the recovery phase

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It is also reported that the signaling cascades regulating Fe 2+ production were activated in RGCs isolated 24 h post RIR, which prompted the simultaneous induction of multiple genes implicated in ferroptosis and other types of RCD (97)

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