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Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility

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The symptoms may consist of mild local irritation (localized erythema and itching), severe local irritation varying from erythematous alopecia to erosions, ulceration, oedema, and purulent discharges with crusting or, in the most severe cases, generalized dermatitis with secondary pyoderma and systemic illness (Muller, 1970)