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323,324,325 Specifically, activation of GLP-1R leads to an increase in cAMP levels, which in turn activates PKA, a widely regulating enzyme of cellular functions, capable of phosphorylating a variety of target proteins, thereby initiating the PKA/CREB signaling pathway

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This distinction is important, as enclomiphene may help maintain the normal feedback mechanisms in the body and potentially minimize the risk of long-term complications associated with traditional testosterone replacement therapy