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demonstrated that ferroptosis, accompanied by decreased FNDC5 expression, occurs in both STZ-induced type 1 diabetic mouse bone tissue and high glucose-exposed MC3T3-E1 cells, with irisin administration or FNDC5 overexpression ameliorating type 1 diabetic bone loss via inhibition of endoplasmic reticulum stress-mediated ferroptosis [177]

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Weight:100 g (3.53 oz)

These data suggest a possible explanation for the differential response of these cell lines to combining PRDX1 perturbations with DNAPKi