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The Sikiric group has consistently characterized BPC-157 as resistant to degradation in human gastric juice, a property attributed to its compact 15-residue length, its five proline residues (which disrupt protease recognition motifs), and the absence of cysteine-bridge–dependent tertiary structure (Sikiric et al., 2018)

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More minor allergic signs, like itching spreading beyond the injection site or mild rash, warrant discontinuing use and monitoring

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