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Oxidative activity may increase with cigarette smoke, air pollution, poorly controlled blood sugar, obesity and insulin resistance, chronic inflammation, certain infections, kidney or liver dysfunction, and some occupational or environmental exposures

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However, unlike arsenic trioxide, GSAO (Dilda et al., 2005b) or PENAO (Dilda et al., 2009), Darinaparsin activity is unaffected by the expression of ABCC1 (MRP-1), modulation of GSH levels (Diaz et al., 2008) and heme-oxygenase inhibition (Garnier et al., 2013)