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While several studies support that localized apoptotic events are needed for mature megakaryocytes to rearrange their cytoplasmic architecture and proceed with proplatelet extension and platelet release, more recent information hold the notion that apoptosis must be restrained during proplatelet formation, and only when platelets have been released, the remaining naked nuclei undergoes apoptosis (reviewed by McArthur 45 )

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These reports remain individual experiences, not controlled outcomes