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CKD-MBD occurs in nearly every patient with stage 5 CKD (eGFR 14 grams) decreased the effectiveness of ACE inhibitor therapy and increased the risk for kidney failure

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Two subgroups of cytosolic GSTs have been characterized based upon their interaction with glutathione: the Y-GST group, which uses a tyrosine residue to activate glutathione, and the S/C-GST, which instead uses serine or cysteine residues

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