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Food nutrients are known to have powerful antioxidant and anti-inflammatory properties for maintaining cellular redox homeostasis by activating antioxidant defense systems such as the nuclear factor erythroid 2–related factor 2 (Nrf2) pathway and the phase II detoxification genes and enzymes including heme oxygenase-1 (HO-1), heat shock protein 70 (Hsp70), sirtuin-1 (Sirt1), GPx, thioredoxin (Trx), SOD, and CAT for neuroprotection during OS and neurotoxicity that lead to the onset and progression of neuropsychiatric disorders such as ADHD [79,80,81]

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These data suggest that EPACs are induced early in melanomagenesis and contribute to primary tumor growth by regulation of redox homeostasis, mitochondrial ROS, and glycolytic metabolism through activation of mTORC1-HIF-1α-TXNIP signaling

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