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Other Protein Targets Similar to the cytokine targets described above, many other important proteins also play remarkable roles in the pathogenesis of RA, and corresponding agents have been used in clinical settings as part of continuous research into treating RA ( Table 1 )

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Phenylephrine (PE), acetylcholine (ACh), L-NAME, hemoglobin and sodium nitroprusside (SNP) were purchased from Sigma Chemical Company (St