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Methods: The study was nested in the CERES study (CEROM approval 78/23), and included all patients receiving thrombectomy at a single large-volume stroke Hub (Bufalini Hospital, Cesena) 2017-2024 for the development cohort, with external validation in the large Alessandria Hub cohort

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ACE inhibitors (ACEIs) (e.g., first-line antihypertensive drugs, such as lisinopril, enalapril, captopril) are among the most commonly prescribed antihypertensive drugs and are widely used in the treatment of cardiovascular disorders [66]