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Doses tested were 250mg once daily, 250mg twice daily, and 500mg once daily and all three showed a statistically significant reduction in melanin index compared with placebo, measured using a handheld device called a mexameter

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[DOI] [PubMed] [Google Scholar] Sanacora G, Kendell SF, Levin Y, Simen AA, Fenton LR, Coric V, et al

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