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However, a one-year randomized, double-blind, placebo-controlled trial in 253 elderly (≥65 years) adults with elevated homocysteine levels found that B vitamin supplementation (1,000 μg/day of folate, 10 mg/day of vitamin B 6 , and 500 μg/day of vitamin B 12 ) did not improve measures of cognitive function, including memory, despite lowering homocysteine levels (116)

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Plasma concentrations decline significantly with age — from approximately 200 ng/mL at age 20 to ~80 ng/mL by age 60 — making it a compelling target for age-related tissue maintenance and periodontal health