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Nevertheless, although BPC 157 lacks general standard neurotransmitter criteria, a network of interconnected evidence has demonstrated that BPC 157 therapy counteracts, in addition to NO-system disturbances, also dopamine, serotonin, glutamate, GABA, adrenalin/noradrenalin, and acetylcholine disturbances, whether specifically related to their receptors, including both blockade and over-activity, destruction, depletion, tolerance, and sensitization, and there is also channel disturbance counteraction [6,9]
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According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment
