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However, with the progression of RA disease, with long-term or severe hypoxia, excessive autophagy of FLS triggers autophagy stress, induces damage to cell structure, and then causes continuous damage to cells, leading to RA pathological conditions such as maintaining synovial inflammation, promoting bone destruction, and destroying immune system homeostasis (89)
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Currently, no specific laboratory monitoring is required, though tracking inflammatory markers can provide objective evidence of therapeutic effect