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In the STEP 1 extension, participants who had lost a mean 17.3% of body we… In SURMOUNT-1, tirzepatide at 15 mg weekly reduced body weight by 20.9% over 72 weeks, against 3.1% on placebo — among the largest reductions recorded for any drug studied i… Short answer: yes on the narrow question, no on the broad one

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Studied extensively in wound-closure and dermal-ageing models