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Counteracted corneal insensitivity following local eye application [17] occurred along with counteraction of the local anesthetic’s effects of intraplantar application, axillary block, spinal block, arrhythmias, and seizures [201,202]

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Namely, the irreversible monoamine oxidase (MAO B) inhibition (i.e., pargyline) and subsequent serotonin substrate (L-tryptophan as a serotonin precursor) induced fore paw treading, hind limbs abduction, wet dog shake, and hypothermia followed by hyperthermia in rats, which commonly occur in serotonin syndrome [66]