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Homocysteine reduction: NAC has been shown to lower plasma homocysteine levels by 11.5% at a dose of 1,800 mg/day in patients with hyperhomocysteinemia, likely through a disulfide exchange reaction (Ventura et al., Pharmacology, 2003) [66]

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The pellets were resuspended in RIPA buffer and centrifuged at 14,000 × g to acquire nuclear extracts