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“The increase in the number of approved new drug products with molecular properties beyond the Rule of Five is explained by incremental and concurrent advances in analytical technologies, molecular biology, target diversity, drug design, medicinal chemistry, predictive modeling, DMPK, drug metabolism and pharmacokinetics, and drug delivery.” He adds that lipid-based formulations, in particular amorphous solid dispersions, are leading the trend in novel oral drug delivery technologies reaching the market, with approvals of novel and advanced excipients tailored to specific applications facilitating this trend